MACC1 Polyclonal Antibody, 20ul Live Cell Imaging Upon binding to 17beta-estradiol or

Upon binding to 17beta-estradiol or related ligands

such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2)

Cyclin D1 encoded by CCND1 belongs to the highly conserved cyclin family

It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin

MACC1 Polyclonal Antibody, 20ul Live Cell Imaging Upon binding to 17beta-estradiol orMACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409) HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis free survival (Stein et al. 2009 [PubMed: 19098908]).