Stathmin(Phospho-Ser16) Rabbit Polyclonal Antibody, 100ul Bottle-Top Dispenser Proteolytic processing of this protein

Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity| indicating a role as a negative regulator of CDC2/cyclin A

|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively

The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression

Stathmin(Phospho-Ser16) Rabbit Polyclonal Antibody, 100ul Bottle-Top Dispenser Proteolytic processing of this proteinThis gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A