Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter Multiple alternatively spliced variants

Multiple alternatively spliced variants

COP9 signalosome complex subunit 5 encoded by COPS5 is one of the eight subunits of COP9 signalosome

Involved in protein trafficking

We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter Multiple alternatively spliced variantsMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.