IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath The encoded protein also is

The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain

Expressed predominantly in the brain

A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases

including those involved in energy metabolism

IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath The encoded protein also isITPR1 (inositol 1,4,5 trisphosphate receptor type 1) encodes an intracellular receptor for inositol 1,4,5 trisphosphate. Upon stimulation by inositol 1,4,5 trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for ITPR1.