Ref-1 Polyclonal Antibody, 20ul[BT-AP07734] Glassware Sets a positive regulator of programmed

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Ref-1 Polyclonal Antibody, 20ul[BT-AP07734] Glassware Sets a positive regulator of programmedApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.

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