Shc Polyclonal Antibody, 50ul[BT-AP08289] Cell Proliferation The encoded protein is an

The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification

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Rho family small GTPases

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Shc Polyclonal Antibody, 50ul[BT-AP08289] Cell Proliferation The encoded protein is anSHC1 (SHC adaptor protein 1) encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in