Histone H3 Polyclonal Antibody, 20ul[BT-AP04089] Human Genome Knockout Libraries Mutations in APP have been

Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy)

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Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer

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Histone H3 Polyclonal Antibody, 20ul[BT-AP04089] Human Genome Knockout Libraries Mutations in APP have beenHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin