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Targeting the hepatic secretome or hepatocyte nuclear factors (HNFs) has shown to modulate lipid and glucose metabolism and reduce the complication risk of diabetes (61)

AOM semaglutide also showed its largest quarter-over-quarter percentage point increase since the start of the study period, a trend likely driven by approval of the oral formulation of Wegovy in late 2025

However, few prospective studies have conducted prespecified, systematic causal pathway analyses linking these metabolic improvements to reproductive endpoints such as ovulation, clinical pregnancy, or live birth rates

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