HSH2D Rabbit Polyclonal Antibody, 100ul Electrophoresis & Labeling The encoded preproprotein is secreted

The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer

Multiple transcript variants have been described

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The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family

HSH2D Rabbit Polyclonal Antibody, 100ul Electrophoresis & Labeling The encoded preproprotein is secretedT cell activation requires 2 signals: recognition of antigen by the T cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al. 2003