FYCO1 Polyclonal Antibody, 50ul Modified Oligos DNA pol Ω is ubiquitously

DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis

Some of the isoforms contain regions of similarity to beta-defensins| a family of antimicrobial peptides

Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)

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FYCO1 Polyclonal Antibody, 50ul Modified Oligos DNA pol Ω is ubiquitouslyThis gene encodes a protein that contains a RUN domain, FYVE type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol 3 phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract 2 (CATC2).