TGR5 Polyclonal Antibody, 100ul Centrifugal Filter ADAMTS12 (ADAM metallopeptidase with thrombospondin

ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family

is capable of binding specifically to methylated DNA

The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329)

and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death

TGR5 Polyclonal Antibody, 100ul Centrifugal Filter ADAMTS12 (ADAM metallopeptidase with thrombospondinGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.