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Dual GIP / GLP-1 Mechanism 4 Tirzepatide acts on both GIP and GLP-1 receptors

This non-standard amino acid prevents DPP-4 enzymatic cleavage that would rapidly degrade the peptide, stabilises the helical structure important for receptor binding, and substantially extends biological half-life

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Ceftolozane/tazobactam resistance and mechanisms in carbapenem-nonsusceptible Pseudomonas aeruginosa