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Patients on insulin or oral diabetes medications may need monitoring or dose adjustments

Mechanistically, echinatin activates nuclear factor, erythroid-derived 2, like 2 (Nrf2)/glutamate-cysteine ligase catalytic subunit (GCLC)/glutamate-cysteine ligase, modifier subunit (GCLM) signaling axis, which maintains the GSH homeostasis and thereby inhibits ferroptosis