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Samples contained 0.2 M protein in reaction buffer (100 mM K 2 HPO 4 /KH 2 PO 4 pH 7.4, 1 mM EDTA) and 10 mM total dithiothreitol (DTT) for full reduction or 10 mM total H 2 O 2 for full oxidation of the sensor, respectively

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Relationship between frequency of SHMT-C1420T and latitude The T allele frequency of the cSHMT-C1420T polymorphism across Eurasia is shown in Figure 2