PRMT1-2e - Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor. CAS# 17328-16-4 ethyltransferase Lysosomotropism of basic cathepsin K

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

CAS Number: 844499-71-4

Small molecule modulation of Smoothened activity

InChi: InChI=1S/C8H12N4S3/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12/h1-2H

PRMT1-2e - Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor. CAS# 17328-16-4 ethyltransferase Lysosomotropism of basic cathepsin KPRMT1 2e, CAS No. 17328 16 4, is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1. 5 M. It has no activity against CARM1 and Set7 9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1. 97 M) and LNCaP prostate cancer cells (IC50 ~4. 49 M). It can attenuate androgen induced gene expression in LNCaP cells. Product information CAS Number: 17328 16 4 Molecular Weight: