Vadimezan (DMXAA) lase 1038/s41598-020-58587-2

1038/s41598-020-58587-2

Di Giorgio C

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM)

Meisterhans C

Vadimezan (DMXAA) lase 1038/s41598-020-58587-2Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti tumor activity of tumor associated macrophages. Product information CAS Number: 117570 53 3 Molecular Weight: 282. 29