Brigatinib-analog - CAS# 1197958-12-5 60061 CADTH Canadian Drug Expert Committee

CADTH Canadian Drug Expert Committee Recommendation: Obeticholic Acid (Ocaliva — Intercept Pharmaceuticals Canada): Indication: Primary biliary cholangitis [Internet]

Stafford CA

[Epub ahead of print] PubMed PMID: 26317790

43(5):645-56

Brigatinib-analog - CAS# 1197958-12-5 60061 CADTH Canadian Drug Expert CommitteeBrigatinib analog, CAS No. 1197958 12 5, is an orally active, potent and selective anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) inhibitor. Brigatinib analog is structurally related to Brigatinib (AP 26113). Brigatinib analog binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and