FRAX597 Catalog No.:M9936-10 medium conditioned by SKOV3ip cells

medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment

Chemical Name: 4-(2-(2

1191911-26-8

Smiles: CC(C)C1=CC(=CC(C(C)C)=C1CC(=O)NS(=O)(=O)OC1C(=CC=CC=1C(C)C)C(C)C)C(C)C

FRAX597 Catalog No.:M9936-10 medium conditioned by SKOV3ip cellsFRAX597 is a potent and selective inhibitor of the p21 activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2) associated Schwannomas. FRAX597 inhibits the proliferation of NF2 deficient schwannoma cells in culture and displayed potent anti tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP competitive Group I PAK inhibitors