RAF265 alapril D5 maleate Investigation of tumor cell targeting

Investigation of tumor cell targeting of a dendrimer nanoparticle using a double-clad optical fiber probe

InChi: InChI=1S/C15H20N2O2

InChiKey: XZYXCQXTKOYHGK-UHFFFAOYSA-N

PP-121 also blocks tyrosine phosphorylation induced by v-Src in NIH3T3 cells transformed with v-Src(Thr338)

RAF265 alapril D5 maleate Investigation of tumor cell targetingCHIR 265 is an orally bioavailable small molecule with potential antineoplastic activity. CHIR 265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR 2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras Raf MEK ERK signaling pathway and are frequently