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First, in a 48-week Phase 2 trial published in the New England Journal of Medicine , adults with obesity who took the highest dose lost an average of 24.2% of their body weight , roughly 53 pounds for a 220-pound patient.[1] No obesity drug has ever produced larger numbers in a randomized trial

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Research literature around IGF-1R and mTOR pathway modelling highlights the importance of IGF-1R-PI3K-Akt-mTOR signalling in complex cellular network analysis