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This is the dose studied in every FDA registration trial and the dose carried forward in long term extension work

In HT-29 cells, luteolin downregulates anti-apoptotic proteins and induces cell cycle arrest (115)

It is important to note that a highly electrophilic metabolite has a tendency to react with tissue nucleophilic groups such as -OH, -NH 2 and -SH and precipitate toxicities such as tissue necrosis, carcinogenesis, mutagenesis, teratogenesis, etc

The clinician takes a thorough medical history, asks about current symptoms such as pelvic pain, menstrual changes, fertility concerns, or signs of systemic inflammation, and notes prior treatments and medication use