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JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26

JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26

Name: JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26
Brand: matisco.be
SKU: 71434341206
Price: 155.00 USD
Availability: InStock
Rating: 4.855 (13 reviews)

SKU: 71434341206

4.9

PLN155.00 PLN205.00

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JNJ-40411813 mifugin InChi: InChI=1S/C24H23F3N4O2/c25-24(26JNJ 40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ 40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 42 nmol L in a [(35)S]GTPS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 29 nmol L in a Ca(2+) mobilization assay with hmGlu2 G 16 cotransfected HEK293 cells. JNJ 40411813 displaced [(3)H]JNJ 40068782 and [(3)H]JNJ 46281222 (mGlu2 receptor PAMs),

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Description

InChi: InChI=1S/C24H23F3N4O2/c25-24(26

Chemical Name: 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6

Su-11274 exhibits greater than 50-fold selectivity for Met versus Flk and more than 500 times selectivity versus other tyrosine kinases such as FGFR-1

InChi: InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H

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