A769662 - AMPK Activator. CAS# 844499-71-4 size:10mg solid 374(4):323-32

374(4):323-32

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

Molecular Weight: 618

4-oxadiazol-5-yl)piperidin-1-yl)methanone

A769662 - AMPK Activator. CAS# 844499-71-4 size:10mg solid 374(4):323-32A769662, CAS No. 844499 71 4, is a potent and selective small molecule activator of AMP activated protein kinase (AMPK). It induces allosteric activation of AMPK and inhibition of dephosphorylation of AMPK on Thr 172, similar to the effects of AMP. The activation of AMPK inhibits mTOR signaling, which is a positive effector of cell growth and survival. A769662 stimulated partially purified rat liver AMPK with an EC50 of 0. 8 M and inhibited fatty acid