C(=O)NS(C)(=O)=O](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10848_1621562573.gif?v=1621562574)
VTP-27999 0264 Smiles: CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)NS(C)(=O)=O
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VTP-27999 0264 Smiles: CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)NS(C)(=O)=OVTP 27999 is a highly potent and selective renin inhibitor (IC50 = 0. 47 nM). It exhibits >1000 selectivity for renin over >150 receptors, ion channels and enzymes. Renin is an asparyl protease that cleaves angiotensinogen into angiotension I in the plasma. It functions as a regulator of blood pressure and sodium homeostasis. In vitro, VTP 27999 increases renin immunoreactivity by 30%, it bind to acid activated, intact prorenin and promotes
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