T-5224 Catalog No.:M8650-2 NF-κB and PI3K/AKT/mTOR pathways are

NF-κB and PI3K/AKT/mTOR pathways are involved in the protective effect of AZ3451

InChi: InChI=1S/C30H32F6N4O2/c1-28(2

A Dooms-Goossens

thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors

T-5224 Catalog No.:M8650-2 NF-κB and PI3K/AKT/mTOR pathways areT 5224 is a selective inhibitor of c Fos activator protein 1. T 5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T 5224 has been investigated in phase II human clinical trials. T 5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP 1) is a pivotal transcription factor that regulates a wide range of cellular processes