SC-514 - CAS# 354812-17-2 Catalog No.:M6663-2 Expert Rev Anticancer Ther

Expert Rev Anticancer Ther

Currently it is in Phase II/III clinical trials for Hodgkin's lymphoma and advanced breast cancer

indicating that the drug directly interacts with tubulin at the colchicine-binding site

It was being developed by Schering-Plough

SC-514 - CAS# 354812-17-2 Catalog No.:M6663-2 Expert Rev Anticancer TherSC 514, CAS No. 354812 17 2, is a selective and reversible inhibitor of IB kinase 2 (IKK2) that may target osteoclastogenesis. SC 514 dose dependently inhibits RANKL induced osteoclastogenesis and induced apoptosis and caspase 3 activation in RAW264. 7 cells. Targeting IKK by SC 514 may be a potential treatment for osteoclast related disorders such as osteoporosis and cancer induced bone loss. Product information CAS Number: 354812 17 2 Molecular