AZD2858 46040 Exatecan mesylate inhibits topoisomerase I

Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks

4-dihydroxy-6-methyl-5-{[(1S

InChi: InChI=1S/C14H20Br2N2

which is comparable with the response seen with activated wt mALK

AZD2858 46040 Exatecan mesylate inhibits topoisomerase IAZD2858 is a potent and GSK 3 inhibitor with an IC50 of 68 nM. AZD 2858 inhibits tau phosphorylation at the S396 site, and it activates Wnt signaling pathway. AZD2858 has a substantial impact on fracture healing. The fractures healed with a bony callus without an obvious endochondral component, suggesting that AZD2858 drives mesenchymal cells into the osteoblastic pathway. Product information CAS Number: 486424 20 8 Molecular Weight: 453. 52 Formula: