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ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine

ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine

Name: ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine
Brand: matisco.be
SKU: 87970990701
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SKU: 87970990701

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ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotineONT 093, CAS No. 216227 54 2, also known as OC 144 093, is an orally bioavailable P glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT 093 could inhibit P gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144 093 is the least non specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60

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Description

Aticaprant (CERC-501) alleviates the nicotine withdrawal syndrome

(2011) Cancer Research

PubMed PMID: 23228983

The decreased expression could be related to the increased liver Fe in both Dp44mT- and 3-AP-treated mice

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