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Melanosis coli can develop within a few months of using herbal laxatives with anthraquinone-containing plants such as: Senna Aloe Cascara Rhubarb Risk Factors Although chronic laxative use is the most common cause of melanosis coli, other factors can increase the risk of developing the condition, including: Underlying conditions: Melanosis coli sometimes develops in people with inflammatory bowel disease (IBD) or chronic diarrhea

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