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239,241 RAGE antagonists are being explored to block the downstream effects of AGE-RAGE interactions to reduce inflammation and oxidative stress in DPN

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reported the therapeutic advantage of targeting SOD as a treatment for type-2 DN through the renal AMPK-PGC-1-Nrf2 and AMPK-FoxO signaling pathways (AMP-activated protein kinase-peroxisome proliferator-activated receptor coactivator 1 (PGC-1)-nuclear factor erythroid 2-related factor 2 and AMPK-forkhead box O transcriptional factors)

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