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However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies

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Equally vital are reality checks, self-exclusion options, and limit-setting tools that help maintain healthy habits, especially during winning or losing streaks when emotions can cloud judgment

If tiredness is severe, worsening or lasting beyond the adjustment period, a healthcare provider can help determine whether semaglutide is the cause or if something else may be contributing